Resultados
Resultados previos
El laboratorio de Nutrición de Precisión es un referente en el uso de estrategias de nutrición personalizada para la modulación del metabolismo.
NutriSI-ON es un proyecto interdisciplinar en el que trabajan dos grupos con capacidades y experiencias complementarias y sinérgicas para dar lugar a un nuevo enfoque de la nutrición de precisión en inmunología.
Entre los resultados más relevantes asociados al programa se pueden destacar publicaciones científicas de los últimos 5 años
Study to Childhood Obesity Prevention
Marcos-Pasero H, Aguilar-Aguilar E, de la Iglesia R, Espinosa-Salinas I, Molina S, Colmenarejo G, Martínez JA, Ramírez de Molina A, Reglero G, Loria-Kohen V. "GENYAL" Methodology and Preliminary Results. Front Nutr. 2022 Mar 8;9:777384. doi: 10.3389/fnut.2022.777384. PMID: 35350411; PMCID: PMC8957940.
The Chemokine Receptor CCR5
Blanco R, Gómez de Cedrón M, Gámez-Reche L, Martín-Leal A, González-Martín A, Lacalle RA, Ramírez de Molina A, Mañes S. Links Memory CD4+ T Cell Metabolism to T Cell Antigen Receptor Nanoclustering. Front Immunol. 2021 Dec 7;12:722320. doi: 10.3389/fimmu.2021.722320. PMID: 34950130; PMCID: PMC8688711.
Intestinal Intervention Strategy Targeting Myeloid Cells to Improve Hepatic Immunity during Hepatocarcinoma Development.
Bouzas Muñoz A, Giménez-Bastida JA, Tejedor AG, Haros CM, Gómez de Cedrón M, Ramírez de
Molina A, Laparra Llopis JM. Biomedicines. 2021 Nov 6;9(11):1633. doi:
10.3390/biomedicines9111633. PMID: 34829862; PMCID: PMC8615385.
Metabolic Health Together with a Lipid Genetic Risk Score Predicts Survival of Small Cell Lung Cancer Patients
Fernández LP, Merino M, Colmenarejo G, Moreno Rubio J, González Pessolani T, Reglero G, Casado E, Sereno M, Ramírez de Molina A. Cancers (Basel). 2021 Mar 5;13(5):1112. doi: 10.3390/cancers13051112. PMID: 33807668; PMCID: PMC7961979.
Precision Nutrition to Activate Thermogenesis as a Complementary Approach to Target Obesity and Associated-Metabolic-Disorders. Cancers (Basel)
Reguero M, Gómez de Cedrón M, Wagner S, Reglero G, Quintela JC, Ramírez de Molina A. 2021 Feb 18;13(4):866. doi: 10.3390/cancers13040866. PMID: 33670730; PMCID: PMC7922953.
Precision Nutrition to Activate Thermogenesis as a Complementary Approach to Target Obesity and Associated-Metabolic-Disorders
Reguero M, Gómez de Cedrón M, Wagner S, Reglero G, Quintela JC, Ramírez de Molina A. Cancers (Basel). 2021 Feb 18;13(4):866. doi: 10.3390/cancers13040866. PMID: 33670730; PMCID: PMC7922953.
Miracle Berry as a Potential Supplement in the Control of Metabolic Risk Factors in Cancer
Gómez de Cedrón M, Wagner S, Reguero M, Menéndez-Rey A, de Molina AR. Antioxidants (Basel). 2020 Dec 15;9(12):1282. doi: 10.3390/antiox9121282. PMID: 33333960; PMCID: PMC7765360.
Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer
Fernández LP, Merino M, Colmenarejo G, Moreno-Rubio J, Sánchez-Martínez R, Quijada-Freire A, Gómez de Cedrón M, Reglero G, Casado E, Sereno M, Ramírez de Molina A. Mol Oncol. 2020 Dec;14(12):3135-3152. doi: 10.1002/1878-0261.12816. Epub 2020 Oct 30. PMID: 33030783; PMCID: PMC7718959.
Saponin-Rich Extracts and Their Acid Hydrolysates Differentially Target Colorectal Cancer Metabolism in the Frame of Precision Nutrition
Gómez de Cedrón M, Navarro Del Hierro J, Reguero M, Wagner S, Bouzas A, Quijada-Freire A, Reglero G, Martín D, Ramírez de Molina A. Cancers (Basel). 2020 Nov 17;12(11):3399. doi: 10.3390/cancers12113399. PMID: 33212825; PMCID: PMC7698026.
Non-Coding and Regulatory RNAs as Epigenetic Remodelers of Fatty Acid Homeostasis in Cancer
Cruz-Gil S, Fernández LP, Sánchez-Martínez R, Gómez de Cedrón M, Ramírez de Molina A. Cancers (Basel). 2020 Oct 9;12(10):2890. doi: 10.3390/cancers12102890. PMID: 33050166; PMCID: PMC7599548.
Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment
Fernández LP, Gómez de Cedrón M, Ramírez de Molina A. Front Oncol. 2020 Oct 28;10:577420. doi: 10.3389/fonc.2020.577420. PMID: 33194695; PMCID: PMC7655926.
Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
Nuevo-Tapioles, C., Santacatterina, F., Stamatakis, K. et al. Nat Commun11, 3606 (2020). https://doi.org/10.1038/s41467-020-17384-1
Dysfunctional oxidative phosphorylation shunts branched-chain amino acid catabolism onto lipogenesis in skeletal muscle
Sánchez-González C, Nuevo-Tapioles C, Herrero Martín JC, Pereira MP, Serrano Sanz S, Ramírez de Molina A, Cuezva JM, Formentini L. EMBO J. 2020 Jul 15;39(14):e103812. doi: 10.15252/embj.2019103812. Epub 2020 Jun 3. PMID: 32488939; PMCID: PMC7360968.
Marigold Supercritical Extract as Potential Co-adjuvant in Pancreatic Cancer: The Energetic Catastrophe Induced via BMP8B Ends Up With Autophagy-Induced Cell Death
Gómez de Cedrón M, Mouhid L, García-Carrascosa E, Fornari T, Reglero G, Ramírez de Molina A. Front Bioeng Biotechnol. 2020 Jan 24;7:455. doi: 10.3389/fbioe.2019.00455. PMID: 32039173; PMCID: PMC6992545.
Yarrow Supercritical Extract Ameliorates the Metabolic Stress in a Model of Obesity Induced by High-Fat Diet
Mouhid, L.; Gómez de Cedrón, M.; Quijada-Freire, A.; Fernández-Marcos, P.J.; Reglero, G.; Fornari, T.; Ramírez de Molina, A. Nutrients 2020, 12, 72. https://doi.org/10.3390/nu12010072
Tolerability and Safety of a Nutritional Supplement with Potential as Adjuvant in Colorectal Cancer Therapy: A Randomized Trial in Healthy Volunteers
Gómez de Cedrón M, Laparra JM, Loria-Kohen V, Molina S, Moreno-Rubio J, Montoya JJ, Torres C, Casado E, Reglero G, Ramírez de Molina A. Nutrients. 2019 Aug 24;11(9):2001. doi: 10.3390/nu11092001. PMID: 31450563; PMCID: PMC6769991.
A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment
Cruz-Gil S, Sánchez-Martínez R, Wagner-Reguero S, Stange D, Schölch S, Pape K, Ramírez de Molina A. PLoS One. 2019 Jul 24;14(7):e0219944. doi: 10.1371/journal.pone.0219944. Erratum in: PLoS One. 2019 Sep 16;14(9):e0222819. PMID: 31339921; PMCID: PMC6655698.
Deciphering the Human Gut Microbiome of Urolithin Metabotypes: Association with Enterotypes and Potential Cardiometabolic Health Implications
Romo-Vaquero M, Cortés-Martín A, Loria-Kohen V, Ramírez-de-Molina A, García-Mantrana I, Collado MC, Espín JC, Selma MV. Mol Nutr Food Res. 2019 Feb;63(4):e1800958. doi: 10.1002/mnfr.201800958. Epub 2018 Dec 3. PMID: 30471188.
ABCA1 overexpression worsens colorectal cancer prognosis by facilitating tumour growth and caveolin-1-dependent invasiveness, and these effects can be ameliorated using the BET inhibitor apabetalone
Aguirre-Portolés C, Feliu J, Reglero G, Ramírez de Molina A. Mol Oncol. 2018 Oct;12(10):1735-1752. doi: 10.1002/1878-0261.12367. Epub 2018 Sep 17. PMID: 30098223; PMCID: PMC6166002.
Association of calcium and dairy product consumption with childhood obesity and the presence of a Brain Derived Neurotropic Factor-Antisense (BDNF-AS) polymorphism
Marcos-Pasero H, Aguilar-Aguilar E, de la Iglesia R, Espinosa-Salinas I, Gómez-Patiño M, Colmenarejo G, de Molina AR, Reglero G, Loria-Kohen V. Clin Nutr. 2019 Dec;38(6):2616-2622. doi: 10.1016/j.clnu.2018.11.005. Epub 2018 Nov 20. PMID: 30501916.
The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging
Cortés-Martín A , García-Villalba R , González-Sarrías A , Romo-Vaquero M , Loria-Kohen V , Ramírez-de-Molina A , Tomás-Barberán FA , Selma MV , Espín JC. Food Funct. 2018 Aug 15;9(8):4100-4106. doi: 10.1039/c8fo00956b. PMID: 30004553.
The role of glycosyltransferase enzyme GCNT3 in colon and ovarian cancer prognosis and chemoresistance
Fernández LP, Sánchez-Martínez R, Vargas T, Herranz J, Martín-Hernández R, Mendiola M, Hardisson D, Reglero G, Feliu J, Redondo A, Ramírez de Molina A. Sci Rep. 2018 May 31;8(1):8485. doi: 10.1038/s41598-018-26468-4. PMID: 29855486; PMCID: PMC5981315.
The transcriptional and mutational landscapes of lipid metabolism-related genes in colon cancer
Fernández LP, Ramos-Ruiz R, Herranz J, Martín-Hernández R, Vargas T, Mendiola M, Guerra L, Reglero G, Feliu J, Ramírez de Molina A. Oncotarget. 2017 Dec 21;9(5):5919-5930. doi: 10.18632/oncotarget.23592. PMID: 29464044; PMCID: PMC5814184.
Novel Polyphenols That Inhibit Colon Cancer Cell Growth Affecting Cancer Cell Metabolism. J Pharmacol
Gómez de Cedrón M, Vargas T, Madrona A, Jiménez A, Pérez-Pérez MJ, Quintela JC, Reglero G, San-Félix A, Ramírez de Molina A. Exp Ther. 2018 Aug;366(2):377-389. doi: 10.1124/jpet.118.248278. Epub 2018 Jun 5. PMID: 29871992.
Targeting the lipid metabolic axis ACSL/SCD in colorectal cancer progression by therapeutic miRNAs
Cruz-Gil S, Sanchez-Martinez R, Gomez de Cedron M, Martin-Hernandez R, Vargas T, Molina S, Herranz J, Davalos A, Reglero G, Ramirez de Molina A: miR-19b-1 role. J Lipid Res. 2018 Jan;59(1):14-24. doi: 10.1194/jlr.M076752. Epub 2017 Oct 26. PMID: 29074607; PMCID: PMC5748493.
MicroRNA-661 modulates redox and metabolic homeostasis in colon cancer.
Gómez de Cedrón M, Acín Pérez R, Sánchez-Martínez R, Molina S, Herranz J, Feliu J, Reglero G, Enríquez JA, Ramírez de Molina A. Mol Oncol. 2017 Dec;11(12):1768-1787. doi: 10.1002/1878-0261.12142. Epub 2017 Nov 6. PMID: 28981199; PMCID: PMC5709620.
Complementary ACSL isoforms contribute to a non-Warburg advantageous energetic status characterizing invasive colon cancer cells.
Sánchez-Martínez R, Cruz-Gil S, García-Álvarez MS, Reglero G, Ramírez de Molina A. Sci Rep. 2017 Sep 11;7(1):11143. doi: 10.1038/s41598-017-11612-3. PMID: 28894242; PMCID: PMC5593891.
Precision Nutrition for Targeting Lipid Metabolism in Colorectal Cancer
Aguirre-Portolés C, Fernández LP, Ramírez de Molina A. Nutrients. 2017 Sep 28;9(10):1076. doi: 10.3390/nu9101076. PMID: 28956850; PMCID: PMC5691693.
En el grupo de Nutrición de Precisión se han defendido en los últimos cinco años varias tesis doctorales
Lipchronic® as an antitumor and immunomodulatory agent in lung cancer
Adrián Bouzas. UAM. Abril 2022.
Identification of the molecular effect of bioactive compounds for the development of effective nutritional supplements in achieving healthy aging through precision nutrition
Marina Reguero Simón. Universidad Autónoma de Madrid, (UAM) Facultad de Ciencias. Noviembre 2021
Analysis of the effect of bioactive compounds on cancer as personalized complementary agents
Jorge Martínez Romero.UAM. 22/11/19.
Formulations for personalized nutrition of cancer patients
Lamia Mohuid. UAM. 01/02/2019.
Metabolic alterations in cancer and their effect on the epithelial-mesenchymal transition
Silvia Cruz Gil. UAM. 18/01/2019.
Además, dos tesis más están en vías de desarrollo
Study of bioactive compounds derived from Synsepalum dulcificum on the modulation of pathways involved in chronic diseases and their validation by Precision Nutrition
Sonia Wagner. UAM. Fecha de lectura estimada: Diciembre 2023.
Clinical features and lipid metabolism genes as potential biomarkers in lung cancer
María Merino. UAM. Fecha de lectura estimada: 9 de junio de 2023.
Asimismo, el grupo tiene presentadas dos patentes relacionadas, ambas transferidas a la industria
Sistemas lípidos portadores de compuestos bioactivos. Organismos: Universidad Autónoma de Madrid, IMDEA Alimentación, Hospital Infanta Sofía
P201630560/PCT/ES2017/070263: Patente licenciada a Canaan Research and Investment. Patente europea aprobada. Extendida a USA, Brasil, China, India, Canada, Japón y Rusia.
Composición para la reducción del declive metabólico asociado al envejecimiento y/o el tratamiento de trastornos relacionados al metabolismo lipídico
P201830740. Organismos: Hospital La Paz, Universidad Autónoma de Madrid, IMDEA Alimentación, IGEN Pharma. Patente licenciada a Ynsadiet.
Publicaciones Científicas
Merino Salvador M, Fernández LP, Moreno-Rubio J, Colmenarejo G, Casado E, Ramírez de Molina A, Sereno M.Clinical features and lipid metabolism genes as potential biomarkers in advanced lung cancer.2023. Open Acces. BM Cancer. doi: 10.1186/s12885-023-10509-x. 335024.
Fernández LP, Deleyto-Seldas N, Colmenarejo G, Sanz A, Wagner S, Plata-Gómez AB, Gómez-Patiño M, Molina S, Espinosa-Salinas I, Aguilar-Aguilar E, Ortega S, Graña-Castro O, Loria-Kohen V, Fernández-Marcos PJ, Efeyan A, Ramírez de Molina A. Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3' untranslated region. 2022. Open Acces. Genome Biology. 10.1186/s13059-022-02798-5. 5-year IF 20.4; D1. 334664.
Enrique Gabandé Rodríguez, Matilda Pfeiffer and María Mittelbrunn. Immuno(T)herapy for age-related diseases. 2023. Open Acces. EMBO Mol Med. doi: 10.15252/emmm.202216301. 335200.
Montero-Calle A, Gómez de Cedrón M, Quijada-Freire A, Solís-Fernández G, López-Alonso V, Espinosa-Salinas I, Peláez-García A, Fernández-Aceñero MJ, Ramírez de Molina A, Barderas R. Metabolic Reprogramming Helps to Define Different Metastatic Tropisms in Colorectal Cancer. 2022. Open Acces. Front Oncol. 10.3389/fonc.2022.903033. 334663.
Romo-González M, Ijurko C, Alonso MT, Gómez de Cedrón M, Ramirez de Molina A, Soriano ME, Hernández-Hernández Á. NOX2 and NOX4 control mitochondrial function in chronic myeloid leukaemia. 2023. Open Acces. Free Radic Biol Med. doi: 10.1016/j.freeradbiomed.2023.02.005. 335023.
Bouzas A, Gómez de Cedrón M, Colmenarejo G, Laparra-Llopis JM, Moreno-Rubio J, Montoya JJ, Reglero G, Casado E, Tabares B, Sereno M, Ramírez de Molina A. Phenolic diterpenes from Rosemary supercritical extract inhibit non-small cell lung cancer lipid metabolism and synergise with therapeutic drugs in the clinic. 2022. Open Acces. Front Oncol. 10.3389/fonc.2022.1046369. 334665.
Espinosa-Salinas I, Colmenarejo G, Fernández-Díaz CM, Gómez de Cedrón M, Martinez JA, Reglero G, Ramírez de Molina A. Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism. 2022. Open Acces. Scientific reports. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065660/. 334648.
Barrero MJ, Cejas P, Long HW, de Molina AR. Nutritional Epigenetics in Cancer. Adv Nutr. 2022 Apr 14:nmac039. doi: 10.1093/advances/nmac039. Epub ahead of print. PMID: 35421212.
Participaciones en Congresos
Precision nutrition approaches for metabolic health and immune system modulation in cancer and chronic diseases. Cristina Mª Fernández*, Lara P. Fernández*, Gonzalo Colmenarejo, Isabel Espinosa-Salinas, Susana Molina, María Merino, Juan Moreno-Rubio, Enrique Casado, María Sereno and Ana Ramírez de Molina. 8th International Conference on Systems Biology of Mammalian Cells SBMC. Heidelberg May 16-18th 2022 “From Systems Medicine towards Digital Health”.
- METABOCANCER Meeting on Cellular and Systemic Interactions between Cancer and Metabolism. Madrid, Spain, 07-08/07/2022.
- 3rd Epigenetics: From Mechanisms to Disease Conference. Cancun, Mexico, 19-22 May, 2022
- New insights into metabolism and mitochondria. Centro de Biología Molecular Severo Ochoa (CBMSO), Madrid, Spain. 8-9/06/2022
Patentes
Application number EP22382471.5: In vitro method for screening, diagnosis and/or prognosis of colorectal cancer.
En los últimos años, el laboratorio de Inmunometabolismo se ha convertido en un referente mundial en su área, tal y como lo avalan en este periodo la concesión del Premio L'Oréal UNESCO Women for Science y de uno de los dos únicos proyectos ERCStarting Grant en la categoría de Ciencias de la Vida que se concedieron en toda España, relacionado con la propuesta de NutriSI-ON. Entre sus publicaciones recientes cabe destacar:
Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm
Oller J, Gabandé-Rodríguez E, Ruiz-Rodríguez MJ, Desdín-Micó G, Aranda JF, Rodrigues-Diez R, Ballesteros-Martínez C, Blanco EM, Roldan-Montero R, Acuña P, Forteza Gil A, Martín-López CE, Nistal JF, Lino Cardenas CL, Lindsay ME, Martín-Ventura JL, Briones AM, Redondo JM, Mittelbrunn M. Circulation. 2021 May 25;143(21):2091-2109. doi: 10.1161/CIRCULATIONAHA.120.051171. Epub 2021 Mar 12. PMID: 33709773; PMCID: PMC8140666.
T cells with dysfunctional mitochondria induce multimorbidity and premature senescence
Desdín-Micó G, Soto-Heredero G, Aranda JF, Oller J, Carrasco E, Gabandé-Rodríguez E, Blanco EM, Alfranca A, Cussó L, Desco M, Ibañez B, Gortazar AR, Fernández-Marcos P, Navarro MN, Hernaez B, Alcamí A, Baixauli F, Mittelbrunn M. Science. 2020 Jun 19;368(6497):1371-1376. doi: 10.1126/science.aax0860. Epub 2020 May 21. PMID: 32439659.
Control of Inflammation by Calorie Restriction Mimetics: On the Crossroad of Autophagy and Mitochondria
Gabandé-Rodríguez, E.; Gómez de las Heras, M.M.; Mittelbrunn, M. Cells 2020, 9, 82. https://doi.org/10.3390/cells9010082
Glycolysis - a key player in the inflammatory response
Soto-Heredero G, Gómez de Las Heras MM, Gabandé-Rodríguez E, Oller J, Mittelbrunn M. FEBS J. 2020 Aug;287(16):3350-3369. doi: 10.1111/febs.15327. Epub 2020 Apr 27. PMID: 32255251; PMCID: PMC7496292.
Mitochondrial activity in T cells.
Desdín-Micó G, Soto-Heredero G, Mittelbrunn M. Mitochondrion. 2018 Jul;41:51-57. doi: 10.1016/j.mito.2017.10.006. Epub 2017 Oct 12. PMID: 29032101.
Interorganelle Communication between Mitochondria and the Endolysosomal System
Soto-Heredero G, Baixauli F, Mittelbrunn M. Front Cell Dev Biol. 2017 Nov 7;5:95. doi: 10.3389/fcell.2017.00095. PMID: 29164114; PMCID: PMC5681906.
Role of exosomes in the protection of cellular homeostasis
Desdín-Micó G, Mittelbrunn M. Cell Adh Migr. 2017 Mar 4;11(2):127-134. doi: 10.1080/19336918.2016.1251000. Epub 2016 Nov 22. PMID: 27875097; PMCID: PMC5351736.
Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses
Baixauli F, Acín-Pérez R, Villarroya-Beltrí C, Mazzeo C, Nuñez-Andrade N, Gabandé-Rodriguez E, Ledesma MD, Blázquez A, Martin MA, Falcón-Pérez JM, Redondo JM, Enríquez JA, Mittelbrunn M. Cell Metab. 2015 Sep 1;22(3):485-98. doi: 10.1016/j.cmet.2015.07.020. Epub 2015 Aug 20. PMID: 26299452; PMCID: PMC5026297.
